Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors.
J Med Chem
; 51(11): 3077-80, 2008 Jun 12.
Article
em En
| MEDLINE
| ID: mdl-18459730
ABSTRACT
Recently, FXIIa was highlighted as an original attractive target for the development of new anticoagulant drugs with low rates of therapy-related hemorrhages. In this work, we describe the development of a new series of 3-carboxamide-coumarins that are the first potent and selective nonpeptidic inhibitors of FXIIa.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Fator XIIa
/
Cumarínicos
/
Amidas
/
Anticoagulantes
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Bélgica