Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics.
Antimicrob Agents Chemother
; 52(8): 2915-8, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18541727
ABSTRACT
Beta-lactam antibiotics (BLAs) are the first-line agents used against group B streptococci (GBS) infection. A clonal set of four independent, invasive GBS isolates with elevated MICs to BLAs were identified that shared a pbp2x mutation (Q557E) corresponding to a resistance-conferring pneumococcal mutation. BLA sensitivity was restored through allelic replacement or complementation with the wild-type pbp2x.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Streptococcus agalactiae
/
Mutação Puntual
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Beta-Lactamas
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Proteínas de Ligação às Penicilinas
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos