Drug-sensitive FGFR2 mutations in endometrial carcinoma.
Proc Natl Acad Sci U S A
; 105(25): 8713-7, 2008 Jun 24.
Article
em En
| MEDLINE
| ID: mdl-18552176
ABSTRACT
Oncogenic activation of tyrosine kinases is a common mechanism of carcinogenesis and, given the druggable nature of these enzymes, an attractive target for anticancer therapy. Here, we show that somatic mutations of the fibroblast growth factor receptor 2 (FGFR2) tyrosine kinase gene, FGFR2, are present in 12% of endometrial carcinomas, with additional instances found in lung squamous cell carcinoma and cervical carcinoma. These FGFR2 mutations, many of which are identical to mutations associated with congenital craniofacial developmental disorders, are constitutively activated and oncogenic when ectopically expressed in NIH 3T3 cells. Inhibition of FGFR2 kinase activity in endometrial carcinoma cell lines bearing such FGFR2 mutations inhibits transformation and survival, implicating FGFR2 as a novel therapeutic target in endometrial carcinoma.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Carcinoma
/
Neoplasias do Endométrio
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Receptor Tipo 2 de Fator de Crescimento de Fibroblastos
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Mutação
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos