Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance.
J Med Chem
; 51(15): 4839-43, 2008 Aug 14.
Article
em En
| MEDLINE
| ID: mdl-18598016
ABSTRACT
HIV protease (PR) is a prime target for rational anti-HIV drug design. We have previously identified icosahedral metallacarboranes as a novel class of nonpeptidic protease inhibitors. Now we show that substituted metallacarboranes are potent and specific competitive inhibitors of drug-resistant HIV PRs prepared either by site-directed mutagenesis or cloned from HIV-positive patients. Molecular modeling explains the inhibition profile of metallacarboranes by their unconventional binding mode.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Compostos de Boro
/
Protease de HIV
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Inibidores da Protease de HIV
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Farmacorresistência Viral
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Metais
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
República Tcheca