In vitro activity of cefditoren and other antimicrobial agents against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in Zaragoza, Spain.
Diagn Microbiol Infect Dis
; 62(2): 210-5, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18715733
ABSTRACT
In vitro cefditoren antimicrobial activity was tested against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in our hospital from January 2005 to May 2006 by agar dilution and broth microdilution method, respectively. MICs were also determined for 13 and 10 comparison drugs, respectively. The pneumococci tested comprised 113 (39.2%) penicillin susceptible, 91 (31.6%) penicillin intermediate, and 84 (29.2%) penicillin resistant. Cefditoren was the most active drug on the basis of the MICs (MIC(90)=0.5 microg/mL), followed by ceftriaxone and levofloxacin (MIC(90)=1 microg/mL). Cefditoren MICs ranged from 0.25 to 1 microg/mL for ceftriaxone-resistant isolates, with a modal MIC of 0.5 microg/mL and an MIC(90) of 1.0 microg/mL. No S. pneumoniae isolates evaluated in this study showed MICs to cefditoren higher than 1 microg/mL (MIC range,
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Infecções Respiratórias
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Streptococcus pneumoniae
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Cefalosporinas
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Haemophilus influenzae
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Antibacterianos
Limite:
Adolescent
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Adult
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Aged
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Humans
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Diagn Microbiol Infect Dis
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Espanha