Pro- and anti-fibrotic effects of TGF-beta in scleroderma.

Sgonc, R; Wick, G

Sgonc, R; Wick, G.

Afiliação

Sgonc R; Division of Experimental Pathophysiology and Immunology, Laboratory of Autoimmunity, Biocenter, Medical University of Innsbruck, Peter-Mayr-Strasse 4a, A-6020 Innsbruck, Austria.

Rheumatology (Oxford) ; 47 Suppl 5: v5-7, 2008 Oct.

Article em En | MEDLINE | ID: mdl-18784145

ABSTRACT

ABSTRACT

The University of California at Davis 200 and 206 (UCD-200/206) lines of chickens have proven to be the animal model that best reflects the situation in human SSc. We have demonstrated a misbalance of pro-fibrotic (TGF-beta1) and anti-fibrotic (TGF-beta2 and -beta3) TGF-beta isoforms as a possible cause for fibrotic alterations in this model. This opens new avenues for diagnosis and therapy for this still intractable condition.

Assuntos

Escleroderma Sistêmico/metabolismo; Pele/metabolismo; Fator de Crescimento Transformador beta/fisiologia; Animais; Galinhas; Fibrose; Modelos Animais; Escleroderma Sistêmico/patologia; Pele/patologia

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Escleroderma Sistêmico / Pele / Fator de Crescimento Transformador beta Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Rheumatology (Oxford) Assunto da revista: REUMATOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Áustria

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