Targeting caspases in intracellular protozoan infections.
Immunopharmacol Immunotoxicol
; 31(2): 159-73, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-18785049
ABSTRACT
Caspases are cysteine aspartases acting either as initiators (caspases 8, 9, and 10) or executioners (caspases 3, 6, and 7) to induce programmed cell death by apoptosis. Parasite infections by certain intracellular protozoans increase host cell life span by targeting caspase activation. Conversely, caspase activation, followed by apoptosis of lymphocytes and other cells, prevents effective immune responses to chronic parasite infection. Here we discuss how pharmacological inhibition of caspases might affect the immunity to protozoan infections, by either blocking or delaying apoptosis.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Infecções por Protozoários
/
Apoptose
/
Inibidores de Caspase
/
Antiprotozoários
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Immunopharmacol Immunotoxicol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
/
TOXICOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Brasil