Alcohol and nicotine consumption exacerbates choroidal neovascularization by modulating the regulation of complement system.
FEBS Lett
; 582(23-24): 3451-8, 2008 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-18789935
ABSTRACT
The objective of the present study was to investigate the effect of alcohol and nicotine consumption on the pathogenesis of choroidal neovascularization (CNV) in rats after laser-photocoagulation. Confocal microscopic analysis demonstrated an increase in CNV complex size in rats fed with alcohol (2.3-fold), nicotine (1.9-fold), and the combination of alcohol and nicotine (2.7-fold) compared with the control groups. Immunohistochemical analysis revealed that alcohol and nicotine consumption increased MAC deposition and VEGF expression in laser spots. Expression of CD59 by RT-PCR and Western blot was drastically reduced in the animals that were fed with alcohol, nicotine and alcohol and nicotine compared to those fed with water alone and this was associated with exacerbation of CNV.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Consumo de Bebidas Alcoólicas
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Neovascularização de Coroide
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Etanol
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Nicotina
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos