[Receptors for advanced glycation end products and their physiological and clinical significance]. / Receptory koncowych produktów zaawansowanej glikacji - znaczenie fizjologiczne i kliniczne.
Postepy Hig Med Dosw (Online)
; 62: 511-23, 2008 Oct 10.
Article
em Pl
| MEDLINE
| ID: mdl-18936727
ABSTRACT
The receptor for advanced glycation end products (RAGE) is a multiligand cell-surface protein and belongs to the immunoglobulin superfamily. RAGE is expressed by different cell types, including macrophages, lymphocytes, endothelial, neuronal, and smooth muscle cells. In addition to advanced glycation end products (AGEs), RAGE binds amphoterin, S100/calgranulin, amyloid, transthyretin, and a leukocyte integrin, Mac-1. Engagement of RAGE in intracellular signaling leads to the activation of the proinflammatory transcription factor NF-kappaB to sustained cellular dysfunction and tissue destruction. In this study a pivotal role of RAGE in the progression of various diseases, i.e. diabetes, inflammation, neurodegeneration, tumors, vascular injury, atherosclerosis, and septic shock, is presented.
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Bases de dados:
MEDLINE
Assunto principal:
Receptores Imunológicos
/
Produtos Finais de Glicação Avançada
Limite:
Animals
/
Humans
Idioma:
Pl
Revista:
Postepy Hig Med Dosw (Online)
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
MEDICINA
/
SAUDE PUBLICA
Ano de publicação:
2008
Tipo de documento:
Article