Combined models for data from in vitro-in vivo correlation experiments.
J Biopharm Stat
; 18(6): 1197-211, 2008.
Article
em En
| MEDLINE
| ID: mdl-18991117
ABSTRACT
A method is presented to describe the in vitro-in vivo correlation (IVIVC) of an extended release drug formulation. This extended release drug product is overencapsulated with immediate release material. The heterogeneity of the capsule is modelled using a combined model of an extended release and an immediate release pharmacokinetic profile. Whereas an IVIVC is conventionally performed using a two-stage procedure, the model uses a one-stage convolution-based method. The method is applied to a Galantamine controlled release formulation, an acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. The average percentage prediction error indicated a good fit of the new model.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Inibidores da Colinesterase
/
Modelos Estatísticos
/
Galantamina
/
Modelos Biológicos
/
Modelos Químicos
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Biopharm Stat
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Bélgica