The cholinergic regulation of potassium (86Rb+) permeability in sweat glands isolated from patients with cystic fibrosis.
Exp Physiol
; 76(4): 573-8, 1991 Jul.
Article
em En
| MEDLINE
| ID: mdl-1910765
ABSTRACT
Sweat glands isolated from skin obtained from normal subjects and patients with cystic fibrosis (CF) were pre-loaded with 86Rb+ and superfused with a physiological salt solution and the rate of 86Rb+ efflux was measured as an indicator of cellular potassium permeability. Acetylcholine always evoked a permeability increase in the glands from control subjects and this response could be resolved into calcium-dependent and calcium-independent components. Sweat glands from CF patients did not show such consistent responses. In three individuals the glands were abnormally insensitive to acetylcholine but normal responsiveness was seen in a fourth case. It is proposed that CF can induce dysfunction of calcium-dependent control processes in sweat glands.
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Bases de dados:
MEDLINE
Assunto principal:
Potássio
/
Glândulas Sudoríparas
/
Acetilcolina
/
Fibrose Cística
Limite:
Humans
Idioma:
En
Revista:
Exp Physiol
Assunto da revista:
FISIOLOGIA
Ano de publicação:
1991
Tipo de documento:
Article