Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation.
N Engl J Med
; 360(7): 692-8, 2009 Feb 12.
Article
em En
| MEDLINE
| ID: mdl-19213682
ABSTRACT
Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
HIV-1
/
Receptores CCR5
/
Transplante de Células-Tronco
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
N Engl J Med
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha