Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells.
J Infect Dis
; 199(9): 1318-22, 2009 May 01.
Article
em En
| MEDLINE
| ID: mdl-19301980
ABSTRACT
Human immunodeficiency virus (HIV)-resistant commercial sex workers provide a unique opportunity to study correlates of protection associated with natural resistance to HIV infection. Emerging data from studies of these individuals and other uninfected individuals who have been exposed to HIV suggest that low levels of immune activation may contribute to protection against infection. In the present study, HIV-resistant individuals were shown to have reduced frequencies of T cells expressing the activation marker CD69. They were also found to have elevated frequencies of regulatory T (T(reg)) cells, compared with HIV-negative control individuals. By controlling levels of T cell activation, T(reg) cells may contribute to HIV resistance by minimizing the pool of cells susceptible to infection.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Trabalho Sexual
/
Linfócitos T CD4-Positivos
/
Antígenos CD4
/
Síndrome da Imunodeficiência Adquirida
/
HIV-1
/
Linfócitos T Reguladores
/
Soronegatividade para HIV
/
Linfócitos T CD8-Positivos
/
Fatores de Transcrição Forkhead
/
Subunidade alfa de Receptor de Interleucina-2
Tipo de estudo:
Risk_factors_studies
Limite:
Female
/
Humans
País/Região como assunto:
Africa
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Canadá