Rosette-forming glioneuronal tumor: report of a chiasmal-optic nerve example in neurofibromatosis type 1: special pathology report.
Neurosurgery
; 64(4): E771-2; discussion E772, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19349806
OBJECTIVE: Rosette-forming glioneuronal tumor is a rare, rather recently described tumor featuring a highly distinctive, biphasic histological pattern, including a cytologically uniform neuronal component of Homer-Wright type pseudorosettes and an accompanying astrocytic element resembling pilocytic astrocytoma. Its occurrence in the posterior fossa and association with the fourth ventricle is stereotypical and a feature of all reported cases. CLINICAL PRESENTATION: In this article, we describe the first rosette-forming glioneuronal tumor arising outside this site, a histologically classic example involving the anterior visual pathway and associated with neurofibromatosis type 1. INTERVENTION: Genetic (fluorescent in situ hybridization) studies demonstrated no large deletion in either normal or neoplastic tissue, indicating that the genetic abnormality underlying neurofibromatosis type 1 in this patient is likely a very small deletion or point mutation. CONCLUSION: The relation of the tumor to the underlying neurofibromatosis type 1 cannot be assessed.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Quiasma Óptico
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Neurofibromatose 1
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Neoplasias do Nervo Óptico
Limite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Neurosurgery
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos