Synthesis of two new hemisynthetic diterpenylhydroquinones from natural ent-labdanes.
Molecules
; 14(6): 2181-94, 2009 Jun 17.
Article
em En
| MEDLINE
| ID: mdl-19553891
ABSTRACT
The synthesis and structural determination of two new diterpenylhydroquinones 2beta-acetoxy-15-phenyl-(22,25-dihydroxy)-ent-labda-8(17),13(E)-diene(1) and 2beta-hydroxy-15-phenyl-(22,25-dihydroxy)-ent-labda-8(17),13(E)-dieneis reported (2). These compounds were obtained by coupling via Electrophilic Aromatic Substitution (EAS) of 1,4-hydroquinone with primary or tertiary allyl alcohol derivatives of the natural ent-labdanes 3 and 4. With this new method, the best results were observed when mixtures of the primary alcohol derivatives 5-6 (26% yield of compound 1) and diol derivatives 9-10 (28% yield of compound 2) were used.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Diterpenos
/
Hidroquinonas
Idioma:
En
Revista:
Molecules
Assunto da revista:
BIOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Chile