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Non-steroidal anti-inflammatory drugs and melanoma risk: large Dutch population-based case-control study.

Joosse, Arjen; Koomen, Elsje R; Casparie, Mariël K; Herings, Ron M C; Guchelaar, Henk-Jan; Nijsten, Tamar.
J Invest Dermatol ; 129(11): 2620-7, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19587697
This case-control study investigates the potential chemoprophylactic properties of non-steroidal anti-inflammatory drugs (NSAIDs) on the incidence of cutaneous melanoma (CM). Data were extracted from the Dutch PHARMO pharmacy database and the PALGA pathology database. Cases had a primary CM between 1991 and 2004, were >or=18 years, and were observed for 3 years in PHARMO before diagnosis. Controls were matched for date of birth, gender, and geographical region. NSAIDs and acetylsalicylic acids (ASAs) were analyzed separately. Adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated using multivariable logistic regression, and the results were stratified across gender. A total of 1,318 CM cases and 6,786 controls were eligible to enter the study. CM incidence was not significantly associated with ever ASA use (adjusted OR 0.92, 95% CI 0.76-1.12) or ever non-ASA NSAID use (adjusted OR 1.10, 95% CI 0.97-1.24). However, continuous use of low-dose ASAs was associated with a significant reduction of CM risk in women (adjusted OR 0.54, 95% CI 0.30-0.99) but not in men (OR 1.01, 95% CI 0.69-1.47). A significant trend (P=0.04) from no use, non-continuous use to continuous use was observed in women. Continuous use of low-dose ASAs may be associated with a reduced incidence of CM in women, but not in men.