Chromatin dynamics associated with HIV-1 Tat-activated transcription.
Biochim Biophys Acta
; 1799(3-4): 275-85, 2010.
Article
em En
| MEDLINE
| ID: mdl-19716452
ABSTRACT
Chromatin remodeling is an essential event for HIV-1 transcription. Over the last two decades this field of research has come to the forefront, as silencing of the HIV-1 provirus through chromatin modifications has been linked to latency. Here, we focus on chromatin remodeling, especially in relation to the transactivator Tat, and review the most important and newly emerging studies that investigate remodeling mechanisms. We begin by discussing covalent modifications that can alter chromatin structure including acetylation, deacetylation, and methylation, as well as topics addressing the interplay between chromatin remodeling and splicing. Next, we focus on complexes that use the energy of ATP to remove or secure nucleosomes and can additionally act to control HIV-1 transcription. Finally, we cover recent literature on viral microRNAs which have been shown to alter chromatin structure by inducing methylation or even by remodeling nucleosomes.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Cromatina
/
Regulação Viral da Expressão Gênica
/
Ativação Transcricional
/
HIV-1
/
Produtos do Gene tat do Vírus da Imunodeficiência Humana
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos