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Morphological comparison of small nerve fibres in gastric mucosa in non-diabetic and Type 2 diabetic subjects.
Jin, H Y; Kang, Y M; Kim, C Y; Kim, S H; Liu, W J; Piao, M H; Park, J H; Baek, H S; Park, T S.
Afiliação
  • Jin HY; Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, 561-712, South Korea.
Diabet Med ; 26(9): 943-6, 2009 Sep.
Article em En | MEDLINE | ID: mdl-19719718
AIM: To determine changes in small nerve fibres in gastric mucosa in patients with Type 2 diabetes by morphological observation. METHODS: In twenty-five non-diabetic and 21 Type 2 diabetic participants, gastric mucosal biopsy under endoscopy was performed. Innervation in gastric mucosa was detected using immunohistochemical staining. Anti-protein gene product (PGP) 9.5 positive nerves underwent morphological observation and quantitative analysis. RESULTS: Small nerve fibres in gastric mucosa were shortened in the diabetic subjects. The ratio of gastric mucosal protrusions maintaining nerve fibres between gastric pits to total observed protrusions was lower in patients with Type 2 diabetes compared with the non-diabetic subjects (ratio of innervated protrusion/total protrusion: 0.49 +/- 0.12 vs. 0.89 +/- 0.06, P < 0.05). CONCLUSIONS: This study sets the scene for further research to investigate the relationship between gastric mucosal nerves and autonomic neuropathy or diabetic peripheral neuropathy.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Mucosa Gástrica / Fibras Nervosas Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Diabet Med Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Coréia do Sul

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Mucosa Gástrica / Fibras Nervosas Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Diabet Med Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Coréia do Sul