Muscle atrophy in cachexia: can dietary protein tip the balance?
Curr Opin Clin Nutr Metab Care
; 12(6): 611-6, 2009 Nov.
Article
em En
| MEDLINE
| ID: mdl-19741519
ABSTRACT
PURPOSE OF REVIEW To review the efficacy of dietary protein supplementation in attenuating muscle atrophy in cachexia. RECENT FINDINGS:
Only very few recent randomized controlled trials have studied the effects of protein supplementation in clinical cachexia. It appears that supplementation of dietary protein (>1.5 g/kg per day) alone or in combination with other anabolic stimuli such as exercise training maintains or even improves muscle mass, but results on muscle function are controversial and no clinical studies have yet directly linked alterations in cellular signaling or metabolic signatures of protein intake-induced muscle anabolism to muscle weight gain.SUMMARY:
To elucidate the role of dietary protein supplementation in attenuating muscle atrophy in cachectic patients, randomized clinical trials are needed in adequately phenotyped patients using sensitive measures of muscle mass and function.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Caquexia
/
Proteínas Alimentares
/
Atrofia Muscular
/
Proteínas
/
Músculo Esquelético
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Clin Nutr Metab Care
Assunto da revista:
CIENCIAS DA NUTRICAO
/
METABOLISMO
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Holanda