[Relationship between serum resistin level and large arterial elasticity in patients with essential hypertension.].
Zhonghua Xin Xue Guan Bing Za Zhi
; 37(3): 244-7, 2009 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-19781150
ABSTRACT
OBJECTIVE:
To investigate the association between serum resistin concentration and large arterial elasticity in patients with essential hypertension (EH).METHODS:
271 recruited subjects were divided into the control group (n = 134) and EH group (n = 137). Blood pressure, waist circumference, hip, body mass index (BMI) were measured. Serum resistin concentration was assessed by enzyme immunoassay, fasting serum insulin and TNF-alpha were measured using radioimmunity kits. Insulin resistance was evaluated by insulin resistance index (HOMA-IR). Brachial ankle pulse wave velocity (baPWV) was tested by the full-automatic arteriosclerosis diagnostic instrument.RESULTS:
(1) The serum resistin concentration, baPWV and TNF-alpha were significantly increased in EH group compared to the control group [(0.65 +/- 0.12) microg/L vs (0.59 +/- 0.13) microg/L; (1513.24 +/- 182.30) cm/s vs (1301.69 +/- 151.15) cm/s; (5.69 +/- 1.98) microg/L vs (3.83 +/- 2.38) microg/L; all P < 0.01]. (2) Pearson correlation analysis showed that resistin was positively correlated with baPWV, TNF-alpha. and HOMA-IR in EH group (r = 0.219, r = 0.212, r = 0.183, P < 0.05 respectively); partial correlation analysis revealed that resistin was positively correlated with baPWV and TNF-alpha (r = 0.238, P < 0.01; r = 0.207, P < 0.05), but not with HOMA-IR. (3) Multivariate regression analysis showed that SBP, age, TNF-alpha, resistin were risk factors of impaired baPWV in EH group (R(2) = 0.368, P < 0.01).CONCLUSION:
Large arterial elasticity was decreased in proportion to increasing serum resistin level in hypertensive patients.
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Bases de dados:
MEDLINE
Assunto principal:
Resistina
/
Índice Tornozelo-Braço
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
Zh
Revista:
Zhonghua Xin Xue Guan Bing Za Zhi
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China