[Genetic diagnosis and prenatal diagnosis of Angelman syndrome].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 26(5): 511-3, 2009 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-19806569
ABSTRACT
OBJECTIVE:
To evaluate the conventional cytogenetic methods in genetic diagnosis and prenatal diagnosis in the family with a proband of Angelman syndrome (AS).METHODS:
High-resolution G-banding karyotyping and fluorescence in situ hybridization (FISH) on metaphase chromosomes were performed.RESULTS:
Two AS patients and 1 normal fetus in the family were successfully detected by FISH.CONCLUSION:
Our result demonstrated that patient with type I AS could be detected by combining the techniques of high-resolution G-banding and FISH with clinical observation, which would offer accurate genetic counseling information to the geneticists and provide the prenatal diagnosis for the AS family.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Diagnóstico Pré-Natal
/
Síndrome de Angelman
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Child, preschool
/
Female
/
Humans
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Infant
/
Male
/
Pregnancy
Idioma:
Zh
Revista:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
2009
Tipo de documento:
Article