Preliminary report: hepatic fat and inflammation in type 2 diabetes mellitus.
Metabolism
; 59(3): 430-2, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-19850309
ABSTRACT
Although the association between inflammation and hepatic fat is fairly established, it remains unclear whether this association is independent of general measures of obesity and standard cardiovascular risk factors. Therefore, the aim of this study was to investigate the contribution of hepatic steatosis as an independent predictor of chronic inflammation in 281 subjects with type 2 diabetes mellitus. Reduced hepatic steatosis significantly (P < .01) correlated with C-reactive protein (r = -0.16) and adiponectin (r = 0.23). The association of hepatic steatosis with both C-reactive protein and adiponectin remained significant after adjustment for age, ethnicity, body mass index (or waist circumference), triglycerides, high-density lipoprotein, and total cholesterol. These data support the concept that accumulation of hepatic fat is related to enhanced inflammation in type 2 diabetes mellitus independent of general measures of obesity and standard cardiovascular risk factors.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Tecido Adiposo
/
Diabetes Mellitus Tipo 2
/
Hepatite
/
Fígado
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Metabolism
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos