Constituents of Polyalthia longifolia var. pendula.
J Nat Prod
; 72(11): 1960-3, 2009 Nov.
Article
em En
| MEDLINE
| ID: mdl-19860383
ABSTRACT
Three new clerodane-type diterpenes, 6alpha,16-dihydroxycleroda-3,13-dien-15-oic acid (1), 6alpha,16-dihydroxycleroda-4(18),13-dien-15-oic acid (2), and 4alpha,18beta-epoxy-16-hydroxyclerod-13-en-15-oic acid (3), and four new protoberberine alkaloids, (-)-8-oxo-10-hydroxy-2,3,9-trimethoxyberberine (4), (-)-8-oxo-2,11-dihydroxy-3,10-dimethoxyberberine (5), (-)-8-oxo-11-hydroxy-2,3,9,10-tetramethoxyberberine (6), and (-)-8-oxo-2,10-dihydroxy-3,9,11-trimethoxyberberine (7), together with 11 known substances, were isolated from a methanol extract of the stems of Polyalthia longifolia var. pendula. The structures of 1-7 were elucidated on the basis of spectroscopic data analysis. Compounds were evaluated for their antiproliferative activities against A549 and MCF-7 cancer cells, and among the substances tested, only 16-oxo-cleroda-3,13-dien-15-oic acid (8) exhibited cytotoxicity.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Alcaloides de Berberina
/
Polyalthia
/
Diterpenos Clerodânicos
/
Antineoplásicos Fitogênicos
Limite:
Female
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China