Transmission dynamic modelling of the impact of human papillomavirus vaccination in the United Kingdom.
Vaccine
; 28(24): 4091-102, 2010 May 28.
Article
em En
| MEDLINE
| ID: mdl-19909831
ABSTRACT
Many countries are considering vaccination against human papillomavirus (HPV). However, the long-term impact of vaccination is difficult to predict due to uncertainty about the prevalence of HPV infection, pattern of sexual partnerships, progression of cervical neoplasias, accuracy of screening as well as the duration of infectiousness and immunity. Dynamic models of human papillomavirus (HPV) transmission were developed to describe the infection spread and development of cervical neoplasia, cervical cancer (squamous cell and adenocarcinoma) and anogenital warts. Using different combinations of assumptions, 9900 scenarios were created. Each scenario was then fitted to epidemiological data and the best-fitting scenarios used to predict the impact of vaccination. Results suggest that vaccinating 12-year-old girls at 80% coverage will result in a 38-82% reduction in cervical cancer incidence and 44-100% reduction in anogenital warts incidence after 60 years of an ongoing vaccination programme if vaccine protection lasts 20 years on average. The marginal benefit of vaccinating boys depends on the degree of protection achieved by vaccinating girls.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Infecções por Papillomavirus
/
Vacinas contra Papillomavirus
/
Modelos Teóricos
Tipo de estudo:
Health_economic_evaluation
/
Incidence_studies
/
Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido