Radiobiology of vestibular schwannomas: mechanisms of radioresistance and potential targets for therapeutic sensitization.
Neurosurg Focus
; 27(6): E2, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-19951055
ABSTRACT
Vestibular schwannomas (VS) are benign tumors arising from the Schwann cells of cranial nerve VIII. Historically the prevailing therapy for patients with VS has been microsurgical resection. More recently, stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy have gained acceptance as effective alternatives. Although the side effect profile and rates of tumor control appear to be favorable for SRS, there is a subset of radioresistant tumors that continue to progress despite properly administered radiation treatment. In this review, the authors summarize what is known about the mechanism of radioresistance in VS at the clinical and molecular level. An improved understanding of the radiobiological behavior of VS may help guide appropriate patient selection for SRS and potentially aid in the design of novel therapies to treat radioresistant tumors.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Tolerância a Radiação
/
Radiobiologia
/
Neuroma Acústico
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Neurosurg Focus
Assunto da revista:
NEUROCIRURGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos