Retention of gene products in syncytial spermatids promotes non-Mendelian inheritance as revealed by the t complex responder.
Genes Dev
; 23(23): 2705-10, 2009 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-19952105
ABSTRACT
The t complex responder (Tcr) encoded by the mouse t haplotype is able to cause phenotypic differences between t and + sperm derived from t/+ males, leading to non-Mendelian inheritance. This capability of Tcr contradicts the concept of phenotypic equivalence proposed for sperm cells, which develop in a syncytium and actively share gene products. By analyzing a Tcr minigene in hemizygous transgenic mice, we show that Tcr gene products are post-meiotically expressed and are retained in the haploid sperm cells. The wild-type allele of Tcr, sperm motility kinase-1 (Smok1), behaves in the same manner, suggesting that Tcr/Smok reveal a common mechanism prone to evolve non-Mendelian inheritance in mammals.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Espermátides
/
Regulação da Expressão Gênica
/
Padrões de Herança
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Genes Dev
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha