Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1.
Genes Dev
; 24(3): 256-64, 2010 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-20080940
ABSTRACT
The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obesity. Here we demonstrate that selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. The failure to increase body mass is mediated, in part, by increased energy expenditure that is associated with activation of the hypothalamic-pituitary-thyroid axis. Disruption of thyroid hormone function prevents the effects of nervous system JNK1 deficiency on body mass. These data demonstrate that the hypothalamic-pituitary-thyroid axis represents an important target of metabolic signaling by JNK1.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Hipófise
/
Glândula Tireoide
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Proteína Quinase 8 Ativada por Mitógeno
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Sistema Hipotálamo-Hipofisário
Limite:
Animals
Idioma:
En
Revista:
Genes Dev
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos