Trisomy 8 and an unbalanced t(5;17)(q11;p11) characterize two karyotypically independent clones in a case of idiopathic myelofibrosis evolving to acute nonlymphoid leukemia.
Cancer Genet Cytogenet
; 52(1): 63-9, 1991 Mar.
Article
em En
| MEDLINE
| ID: mdl-2009512
ABSTRACT
In a patient with idiopathic myelofibrosis (MFI) that had progressed to acute nonlymphoid leukemia (ANLL) after a long-lasting cytotoxic treatment, we observed two karyotypically independent cell populations, one showing trisomy of chromosome 8 as the only anomaly and one with an unbalanced translocation t(5;17)(q11) resulting in partial monosomy of 5q and 17p. The overall karyotypic configuration suggested that chromosome changes occurred as secondary events during the multistep process of leukemogenesis. The probable sequence of cytogenetic events in this patient and a review of the literature indicated that the t(5;17) may represent a therapy-induced abnormality nonrandomly related to the terminal phase of myeloid disorders.
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Bases de dados:
MEDLINE
Assunto principal:
Trissomia
/
Cromossomos Humanos Par 5
/
Cromossomos Humanos Par 8
/
Cromossomos Humanos Par 17
/
Leucemia Mieloide Aguda
/
Mielofibrose Primária
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Itália