Substance P downregulates expression of the high affinity IgE receptor (FcepsilonRI) by human mast cells.
J Neuroimmunol
; 220(1-2): 17-24, 2010 Mar 30.
Article
em En
| MEDLINE
| ID: mdl-20117843
ABSTRACT
The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcepsilonRI) were characterized. SP downregulated expression of FcepsilonRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcepsilonRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Substância P
/
Receptores de IgE
/
Mastócitos
Limite:
Humans
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos