Complete nucleotide sequence and comparative analysis of pPR9, a 41.7-kilobase conjugative staphylococcal multiresistance plasmid conferring high-level mupirocin resistance.
Antimicrob Agents Chemother
; 54(5): 2252-7, 2010 May.
Article
em En
| MEDLINE
| ID: mdl-20211895
ABSTRACT
We have sequenced the conjugative plasmid pPR9, which carries the ileS2 gene, which had contributed to the dissemination of high-level mupirocin resistance at our institution. The plasmid backbone shows extensive genetic conservation with plasmids belonging to the pSK41/pGO1 family, but comparative analyses have revealed key differences that provide important insights into the evolution of these medically important plasmids and high-level mupirocin resistance in staphylococci and highlight the role of insertion sequence IS257 in these processes.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Plasmídeos
/
Staphylococcus aureus
/
Mupirocina
/
Resistência a Múltiplos Medicamentos
/
Antibacterianos
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Espanha