Male development of chromosomally female mice transgenic for Sry.
Nature
; 351(6322): 117-21, 1991 May 09.
Article
em En
| MEDLINE
| ID: mdl-2030730
ABSTRACT
The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.
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Bases de dados:
MEDLINE
Assunto principal:
Análise para Determinação do Sexo
/
Cromossomo Y
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nature
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Reino Unido