Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report.
BMC Neurol
; 10: 32, 2010 May 18.
Article
em En
| MEDLINE
| ID: mdl-20482768
ABSTRACT
BACKGROUND:
To report the clinical course of PML in an apparently immunocompetent patient treated with cidofovir. CASE PRESENTATION A 35-year-old immunocompetent man who developed progressive hemianopsia, aphasia, and limb weakness underwent repeated MRI scans of the brain, spinal fluid analyses, and brain biopsy. Before diagnosis was established based on brain biopsy, he was consecutively treated with methylprednisolone, acyclovir, ceftriaxone and plasmapheresis, but he deteriorated rapidly suggestive of the immune reconstitution inflammatory syndrome (IRIS). He started to recover two weeks after the initiation of treatment with cidofovir and has had no relapse at 3 1/2 years of follow-up. MRI has shown marked improvement.CONCLUSIONS:
PML should be considered in immunocompetent patients with a typical clinical course and MRI findings compatible with PML. Treatment with cidofovir should be considered as early as possible in the disease course.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Leucoencefalopatia Multifocal Progressiva
/
Imunocompetência
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
BMC Neurol
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Noruega