Comprehensive and innovative techniques for liver transplantation in rats: a surgical guide.
World J Gastroenterol
; 16(25): 3120-32, 2010 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-20593497
AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries. RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Transplante de Fígado
/
Modelos Animais
Tipo de estudo:
Evaluation_studies
/
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
World J Gastroenterol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos