Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia.
Mol Cancer
; 9: 226, 2010 Aug 27.
Article
em En
| MEDLINE
| ID: mdl-20799951
ABSTRACT
PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which have diverse functions. Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Leucemia
/
Antígenos de Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Mol Cancer
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido