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Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila.
Aigouy, Benoît; Farhadifar, Reza; Staple, Douglas B; Sagner, Andreas; Röper, Jens-Christian; Jülicher, Frank; Eaton, Suzanne.
Afiliação
  • Aigouy B; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany.
Cell ; 142(5): 773-86, 2010 Sep 03.
Article em En | MEDLINE | ID: mdl-20813263
Planar cell polarity (PCP) proteins form polarized cortical domains that govern polarity of external structures such as hairs and cilia in both vertebrate and invertebrate epithelia. The mechanisms that globally orient planar polarity are not understood, and are investigated here in the Drosophila wing using a combination of experiment and theory. Planar polarity arises during growth and PCP domains are initially oriented toward the well-characterized organizer regions that control growth and patterning. At pupal stages, the wing hinge contracts, subjecting wing-blade epithelial cells to anisotropic tension in the proximal-distal axis. This results in precise patterns of oriented cell elongation, cell rearrangement and cell division that elongate the blade proximo-distally and realign planar polarity with the proximal-distal axis. Mutation of the atypical Cadherin Dachsous perturbs the global polarity pattern by altering epithelial dynamics. This mechanism utilizes the cellular movements that sculpt tissues to align planar polarity with tissue shape.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Polaridade Celular / Drosophila melanogaster Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Polaridade Celular / Drosophila melanogaster Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Alemanha