Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.
Nat Immunol
; 11(10): 912-9, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20818395
ABSTRACT
Caspase-12 has been shown to negatively modulate inflammasome signaling during bacterial infection. Its function in viral immunity, however, has not been characterized. We now report an important role for caspase-12 in controlling viral infection via the pattern-recognition receptor RIG-I. After challenge with West Nile virus (WNV), caspase-12-deficient mice had greater mortality, higher viral burden and defective type I interferon response compared with those of challenged wild-type mice. In vitro studies of primary neurons and mouse embryonic fibroblasts showed that caspase-12 positively modulated the production of type I interferon by regulating E3 ubiquitin ligase TRIM25-mediated ubiquitination of RIG-I, a critical signaling event for the type I interferon response to WNV and other important viral pathogens.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Receptores Virais
/
Febre do Nilo Ocidental
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Vírus do Nilo Ocidental
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Interferon Tipo I
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Caspase 12
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RNA Helicases DEAD-box
Limite:
Animals
Idioma:
En
Revista:
Nat Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos