Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.
Trends Biochem Sci
; 35(12): 669-75, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-20863707
ABSTRACT
Sirtuins are a highly conserved family of proteins whose activity can prolong the lifespan of model organisms such as yeast, worms and flies. Mammals contain seven sirtuins (SIRT1-7) that modulate distinct metabolic and stress response pathways. Three sirtuins, SIRT3, SIRT4 and SIRT5, are located in the mitochondria, dynamic organelles that function as the primary site of oxidative metabolism and play crucial roles in apoptosis and intracellular signaling. Recent findings have shed light on how the mitochondrial sirtuins function in the control of basic mitochondrial biology, including energy production, metabolism, apoptosis and intracellular signaling.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Apoptose
/
Sirtuínas
/
Metabolismo Energético
/
Mitocôndrias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos