Clinical significance of GPR56, transglutaminase 2, and NF-κB in esophageal squamous cell carcinoma.
Cancer Invest
; 29(1): 42-8, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-20874003
ABSTRACT
Proteins do not operate as individual units, and components of intracellular canonical pathways often cross talk in tumor genesis. We hypothesized that G-protein-coupled receptor 56 (GPR56), transglutaminase (TG2), and nuclear factor-κB (NF-κB) may collaborate in interconnected pathways and contribute to the aggressive behavior of esophageal squamous cell carcinoma (ESCC). Immunohistochemical analysis of GPR56, TG2, and NF-κB was carried out using ESCC tissue microarrays. Immunostaining of all the three proteins revealed a significant increase in their expression in ESCCs as compared with normal epithelia and correlated with their concomitant expression. A significant correlation between GPR56, TG2, and NF-κB was observed that correlated with nodal metastasis and tumor invasion in ESCCs.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Esofágicas
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Carcinoma de Células Escamosas
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Biomarcadores Tumorais
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Transglutaminases
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NF-kappa B
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Receptores Acoplados a Proteínas G
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Cancer Invest
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Índia