Genetic predisposition to papillary thyroid cancer.
Endokrynol Pol
; 61(5): 486-9, 2010.
Article
em En
| MEDLINE
| ID: mdl-21049463
ABSTRACT
Approximately 5% of differentiated thyroid cancers are hereditary. Hereditary non-medullary thyroid cancer may occur as a minor component of familial cancer syndromes (e.g. familial adenomatous polyposis) or as a primary feature (familial non-medullary thyroid cancer [FNMTC]). Among FNMTC, PTC is the most common. Although a hereditary predisposition to non-medullary thyroid cancer is well established, the susceptibility genes are poorly known. Up to now, by linkage analysis using microsatellite markers, several putative loci have been described - 1q21, 6q22, 8p23.1-p22, and 8q24; however, validation studies have been unsuccessful. In the present review we discuss the results of linkage analysis and the most recent results of genome wide association studies (GWAS) with high resolution SNP (single nucleotide polymorphism) arrays.
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Bases de dados:
MEDLINE
Assunto principal:
Neoplasias da Glândula Tireoide
Limite:
Humans
Idioma:
En
Revista:
Endokrynol Pol
Ano de publicação:
2010
Tipo de documento:
Article