PU.1 directly regulates retinoic acid-induced expression of RIG-G in leukemia cells.
FEBS Lett
; 585(2): 375-80, 2011 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-21176776
ABSTRACT
RIG-G is a retinoic acid- or interferon-induced gene with potential anti-proliferation function. However, the mechanism underlying ATRA-induced RIG-G induction is not completely understood. Here, we demonstrate that ATRA up-regulates the expression of PU.1, which in turn directly binds to the promoter and increases the expression of RIG-G gene. Luciferase reporter assay and electrophoretic mobility shift assay reveal that PU.1 preferentially binds to one of the two putative binding sites on the RIG-G promoter. Moreover, silencing of PU.1 by shRNA markedly inhibited ATRA- but not IFNα-induced expression of RIG-G. These data provide new insight into the mechanism of ATRA-induced RIG-G expression.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Tretinoína
/
Leucemia
/
Transativadores
/
Proteínas Proto-Oncogênicas
/
Peptídeos e Proteínas de Sinalização Intracelular
Limite:
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China