Aerosol vaccination induces robust protective immunity to homologous and heterologous influenza infection in mice.
Vaccine
; 29(14): 2568-75, 2011 Mar 21.
Article
em En
| MEDLINE
| ID: mdl-21300100
ABSTRACT
Live-attenuated influenza vaccine (LAIV) delivered by large droplet intranasal spray is efficacious against infection. However, many of the large droplets are trapped in the external nares and do not reach the target nasal airway tissues. Smaller droplets might provide better distribution yielding similar protection with lower doses. We evaluated 20 and 30 µm aerosol delivery of influenza virus in mice. A 15s aerosol exposure optimally protected against homologous and heterologous influenza infection and induced a robust immune response. These results demonstrate the feasibility of nasal vaccination using aerosolized particles, providing a strategy to improve vaccine efficacy and delivery.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
/
Vacinação
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Infecções por Orthomyxoviridae
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Aerossóis
Limite:
Animals
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos