A bioinformatic assay for pluripotency in human cells.
Nat Methods
; 8(4): 315-7, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21378979
ABSTRACT
Pluripotent stem cells (PSCs) are defined by their potential to generate all cell types of an organism. The standard assay for pluripotency of mouse PSCs is cell transmission through the germline, but for human PSCs researchers depend on indirect methods such as differentiation into teratomas in immunodeficient mice. Here we report PluriTest, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Biologia Computacional
/
Perfilação da Expressão Gênica
/
Células-Tronco Pluripotentes
Limite:
Humans
Idioma:
En
Revista:
Nat Methods
Assunto da revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Alemanha