Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy.
J Infect Dis
; 204(1): 135-8, 2011 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-21628667
ABSTRACT
Residual plasma viremia (<50 copies/mL) persists in certain human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART); however, the relationship between the degree of residual plasma viremia, the size of HIV reservoirs, and the level of immune activation has not been delineated. Here, we demonstrate that residual plasma viremia correlates with the size of the CD4(+) T cell viral reservoir, but not with markers of immune activation, suggesting that reactivation of the latent viral reservoir may not be the sole source of residual plasma viremia. Novel therapeutic strategies aimed at targeting the source of residual viremia may be necessary to achieve viral eradication.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Plasma
/
Infecções por HIV
/
HIV
/
Provírus
/
Fármacos Anti-HIV
/
Terapia Antirretroviral de Alta Atividade
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos