Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation.
J Transl Med
; 9: 100, 2011 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-21718475
ABSTRACT
BACKGROUND:
Aurora kinase A (AURKA) is a member of serine/threonine kinase family. Several kinases belonging to this family are activated in the G2/M phase of the cell cycle being involved in mitotic chromosomal segregation. AURKA overexpression is significantly associated with neoplastic transformation in several tumors and deregulated Aurora Kinases expression leads to chromosome instability, thus contributing to cancer progression. The purpose of the present study was to investigate the expression of AURKA in non small cell lung cancer (NSCLC) specimens and to correlate its mRNA or protein expression with patients' clinico-pathological features. MATERIALS ANDMETHODS:
Quantitative real-time PCR and immunohistochemistry analysis on matched cancer and corresponding normal tissues from surgically resected non-small cell lung cancers (NSCLC) have been performed aiming to explore the expression levels of AURKA gene.RESULTS:
AURKA expression was significantly up-modulated in tumor samples compared to matched lung tissue (p<0.01, mean log2(FC)=1.5). Moreover, AURKA was principally up-modulated in moderately and poorly differentiated lung cancers (p<0.01), as well as in squamous and adenocarcinomas compared to the non-invasive bronchioloalveolar histotype (p=0.029). No correlation with survival was observed.CONCLUSION:
These results indicate that in NSCLC AURKA over-expression is restricted to specific subtypes and poorly differentiated tumors.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Proteínas Serina-Treonina Quinases
/
Desdiferenciação Celular
/
Neoplasias Pulmonares
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Transl Med
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Itália