Ifosfamide, carboplatin and etoposide in recurrent malignant glioma.
Oncology
; 80(5-6): 330-2, 2011.
Article
em En
| MEDLINE
| ID: mdl-21791942
ABSTRACT
After failure of temozolomide, there is no established standard salvage chemotherapy for patients with recurrent glioblastoma (GBM). Two phase II trials combining ifosfamide, carboplatin and etoposide chemotherapy (ICE) showed favorable results. We therefore applied the ICE protocol to 13 patients (10 GBM, 3 anaplastic astrocytomas). Partial or complete remissions were not observed. None of the 13 patients survived progression-free for 6 months. Our retrospective analysis suggests that the ICE regimen is not effective in patients with recurrent high-grade glioma if applied at second or third relapse.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Astrocitoma
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Neoplasias Encefálicas
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Protocolos de Quimioterapia Combinada Antineoplásica
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Glioma
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Oncology
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Alemanha