Kinesin molecular motor Eg5 functions during polypeptide synthesis.
Mol Biol Cell
; 22(18): 3420-30, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21795388
ABSTRACT
The kinesin-related molecular motor Eg5 plays roles in cell division, promoting spindle assembly. We show that during interphase Eg5 is associated with ribosomes and is required for optimal nascent polypeptide synthesis. When Eg5 was inhibited, ribosomes no longer bound to microtubules in vitro, ribosome transit rates slowed, and polysomes accumulated in intact cells, suggesting defects in elongation or termination during polypeptide synthesis. These results demonstrate that the molecular motor Eg5 associates with ribosomes and enhances the efficiency of translation.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
/
Cinesinas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Biol Cell
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos