Intracellular mechanisms of aminoglycoside-induced cytotoxicity.
Integr Biol (Camb)
; 3(9): 879-86, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21799993
ABSTRACT
Since introduction into clinical practice over 60 years ago, aminoglycoside antibiotics remain important drugs in the treatment of bacterial infections, cystic fibrosis and tuberculosis. However, the ototoxic and nephrotoxic properties of these drugs are still a major clinical problem. Recent advances in molecular biology and biochemistry have begun to uncover the intracellular actions of aminoglycosides that lead to cytotoxicity. In this review, we discuss intracellular binding targets of aminoglycosides, highlighting specific aminoglycoside-binding proteins (HSP73, calreticulin and CLIMP-63) and their potential for triggering caspases and Bcl-2 signalling cascades that are involved in aminoglycoside-induced cytotoxicity. We also discuss potential strategies to reduce aminoglycoside cytotoxicity, which are necessary for greater bactericidal efficacy during aminoglycoside pharmacotherapy.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Aminoglicosídeos
/
Antibacterianos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Integr Biol (Camb)
Assunto da revista:
BIOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos