Lack of evidence for Epstein-Barr virus infection in myasthenia gravis thymus.
Ann Neurol
; 70(3): 515-8, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21905083
ABSTRACT
A role for Epstein-Barr virus (EBV) in myasthenia gravis pathogenesis has been suggested recently. Using in situ hybridization for the detection of the EBV-encoded RNAs and EBNA1-specific immunohistochemistry, we found no latently infected cells in a series of thymus specimens from patients with myasthenia gravis showing lymphofollicular thymitis. In addition, using immunohistochemistry and an antibody specific for the viral immediate early protein BZLF1, no evidence of lytic EBV infection was seen in these cases. Our results therefore do not support a direct role of thymic EBV infection in the pathogenesis of myasthenia gravis.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Timo
/
Infecções por Vírus Epstein-Barr
/
Miastenia Gravis
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
/
Adult
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Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ann Neurol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Alemanha