Neuroprotective effects of neuroglobin after mechanical injury.
Neurol Sci
; 33(3): 551-8, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-21915648
ABSTRACT
Neuroglobin (NGB) is a recently discovered globin, which is widely expressed in vertebrates central and peripheral nervous systems. Previous studies have shown that NGB is important in protecting neurons from hypoxic/ischemic brain injuries. However, there are no reports on the neuroprotective effects of NGB after mechanical injury. Currently, we showed that the NGB expression level in neurons increased continuously from 2 h after injury, and reached a peak at 16 h (p<0.01), after which it decreased sharply. NGB that was overexpressed in mechanically injured B104 cells showed significant neuroprotective effects. Lactate dehydrogenase (LDH) activity decreased and cell survival rates increased (p<0.01, n=5). In the rat model of focal brain trauma, the NGB expression increased sharply at 1 h, after which it increased continuously until it reached a peak at 6 h, and then gradually decreased (p<0.01, n=5). Furthermore, moderate and severe injury resulted in significantly higher NGB levels than did mild injury (p<0.01, n=5). Our results indicate that NGB exerts significant neuroprotective effects after mechanical injury, and thus has important implications for the prognosis and cure of traumatic brain injury.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Lesões Encefálicas
/
Fármacos Neuroprotetores
/
Neurônios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Neurol Sci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China