Strategies for B-lymphocyte repertoire remodeling in transplantation tolerance.
Immunol Res
; 51(1): 1-4, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21948256
ABSTRACT
Transplantation tolerance remains an elusive goal as B-cell-initiated chronic humoral rejection evades current immunosuppression. B-cell-directed therapy is thus emerging as a key component in achieving transplantation tolerance and long-term graft survival. Here, we propose strategies of B-cell repertoire remodeling to achieve humoral unresponsiveness to donor antigens with implementation of fundamental B-cell immunobiology and use of newly developed B-cell-directed agents.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Modelos Imunológicos
/
Tolerância ao Transplante
/
Rejeição de Enxerto
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Sobrevivência de Enxerto
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Immunol Res
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos